In terms of B12 ~~ Methylcobalamin is the form of vitamin B12 our bodies use. If your multivitamin contains cyanocobalamin and if you’re young and don’t have overwhelming symptoms of low vitamin B12 your body will make enough methylcobalamin for you from it. If you are older, have nerve damage or have been battling stress your body won’t be able to make as much methylcobalamin as you may need to recover your health. By using the sublingual form you allow the B12 to go directly into your body via the tissue under your tongue.
If you have B12 malabsorption or pernicious anemia, then sublingual lozenges are the only efficient way for you to take B12 in order for your body to benefit. If you don’t know if you have malabsorption or pernicious anemia, then sublingual lozenges are the best choice because they will for sure work.
Become familiar with “methylcobalamin”, read vitamin labels to see whether that is the vitamin B12 form in the supplement.
Normal nerve cell activity and tissue formation are provided by vitamin B12. Methylcobalamin is the only form of B12 that can be used by the central nervous system. Other forms of B12 must be converted to methylcobalamin. In the conversion some cyanocobalamin gets lost. This is because the liver can’t completely transform the common B12 forms into the superior methylcobalamin form.
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Methylcobalamin is effective in providing healthy brain and spinal cord support. It is required for DNA replication, and production of S-adenosyl-L-methionine (SAMe).
There are many advertisers who sell cyanocobalamin and make it sound effective despite the fact it’s not as effective as methylcobalamin. I trust you will buy what is most beneficial.
Methylcobalamin is the active form of vitamin B12. It can be used by the central nervous system and works immediately.Years ago a doctor put me on antidepressants, “to help your neurotransmitters.” The side affects were weight gain and hair loss. (What’s more depressing than weight gain and hair loss?)
No Side Affects
Methylcobalamin helps neurotransmitters without unwanted side affects. However, be aware that as your blood cells heal and begin properly dividing again you need more potassium to support the additional work your blood cells are doing. Without additional potassium you may experience muscle spasms.
How does methylcobalamin work? The geek answer is: Methylcobalamin “functions in accelerating transmethylation reactions in the manufacture of nucleic acids, neurotransmitters and phospholipids.”
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Lozenges replace B12 effectively
The sublingual form of B12 is absorbed directly into the bloodstream, via the blood vessels under the tongue, and in the cheeks, bypassing the liver and allowing for quick entry into the system.
Dose conversion ~~ Methylcobalamin lozenges vs B12 shots. Dissolving one 1,000mcg methylcobalamin lozenge under your tongue each day for a month will equal one B12 injection a month. Dissolving a 5mg lozenge under your tongue each day for a month will equal, at the end of the month, five B12 shots in that month.
When I had a shot a day, that equaled 30mg a day, or 6 of the 5mg lozenges. When I switched to lozenges I forgot that it had to be for a whole month, so my health deteriorated when I stopped my shots and switched only to the lozenges. If I had remembered about the time required for the lozenges to work equally well, then I wouldn’t have had my symptoms increase because I would have overlapped with shots for some time. Now I’m using lozenges every day with no injections. (9/23/07)
B12 FACTS ~
B12 has the largest, most complex structure of the vitamins.
“Vitamin B12 is unique among vitamins in that it contains a metal ion, cobalt. For this reason cobalamin is the term used to refer to compounds having vitamin B12 activity. Methylcobalamin and 5-deoxyadenosyl cobalamin are the forms of vitamin B12 used in the human body.” Brody T. Nutritional Biochemistry. 2nd ed. San Diego: Academic Press; 1999.
B12 is famously available in meat, dairy, eggs and seafood. But these are less healthy for us today when factory farming adds antibiotics and BP has polluted much of the sea. Today we need to understand that cobalt is in cobalamins (B12), that the basic chemical structure of B12 is the corrin ring, that B12 corrinoids are among the most complicated molecules in nature, involving over 200 atoms and that bacteria and some algae synthesize and contain the corrinoids with the result that Vitamin B12 originates exclusively in microorganisms. Knowing all of this, it turns out that there are other, but less famous, sources of vitamin B12 like tempe, mushrooms, miso and some tea.
Vitamin B12 levels decline with age according to several investigations. Low vitamin B12 impairs nerve function, leading to pins-and-needles sensations, or a burning feeling in the feet, less clear vision, as well as impaired mental function.Vitamin B12 benefits joints and mood.
Vitamin B12 replacement has reduced my back and leg pain.
General information: Vitamin B12, cobalamin is water-soluble and essential for carbohydrate metabolism and energy production. It is vital for neurological activity, including DNA replication, and aids in production of S-adenosyl-L-methionine(SAMe), which benefits joints and mood.
Vitamin B12 is essential for the formation of red blood cells, which are linked to energy levels. Low B12 can cause fatigue. Because B12 is vital for metabolism and energy production, it is useful in weight loss and weight maintenance.
Studies show vitamin B12 provides support for the cardiovascular system. Together with vitamin B6 and folic acid, B12 maintains normal levels of homocysteine, an amino acid found in the blood. Elevated homocysteine levels are associated with increased risk of heart disease, stroke, and additional health concerns, including Alzheimer’s disease and osteoporosis. Plus, elevated homocysteine damages coronary arteries and leads to excessive clotting.
Small amounts of B12 are found in common foods. The amounts of B12 are so tiny that despite eating abundantly of these foods anyone with a malabsorption condition, including bacterial overgrowth in the intestines, may be low on B12. In these cases, additional B12 may be not only desirable but useful.
Absorption ~ About 10 mcg of a 500 mcg vitamin B12 oral supplement is actually absorbed in healthy people. (US gov website attributes this to researcher Ralph Carmel, but the piece they site doesn’t say this.)
Is it safe to take vitamin B12?
My neurologist told me three important things:
- “It can’t hurt you.” He said that repeatedly.
- “Take more when you’re under stress, it will help your body deal with the stress.”
- And, that years ago they diagnosed pernicious anemia, a form of B12 deficiency that is deadly if untreated, by prescribing B12 injections, watching to see if they helped, and then if they did, diagnosing the vitamin B12 illness, pernicious anemia, (because it must have existed if B12 made the symptoms go away).
My neurologist had me keep a Time Line for this very reason, to see if there were changes in my health. The changes were significant.
Memory loss is linked to low vitamin B12, so keep a Time Line. Record your daily symptoms, doses and any serum test results you get. That way you will be able to tell how much you actually improve. If you don’t improve, something else is wrong.
If you have symptoms of low B12, you owe it to yourself to begin taking Methylcobalamin. You need to experience the difference it makes.If your symptoms don’t go away, which rarely happens, then you have some other problem and for sure should go to a doctor for clarification.
In most cases the symptoms will go away or become very much reduced.
You’ll Sleep Better with a Healthy B12 Level ~ Once your B12 levels are restored a small amount of Melatonin will give you a solid night’s sleep. You are going to love this~ and there’s no drugged feeling the next day. Note: research shows that a small dose is more effective than a larger dose.
Melatonin is a natural substance made by the pineal gland located in the brain. Adequate melatonin levels help establish healthy sleep patterns. It is released primarily during the night. Malatonin levels decrease as we get older.
B12 prevents major birth defects
March 2, 2009 ~ Before becoming pregnant, women need to get enough vitamin B12 in addition to folic acid to cut their risk of having a baby with a serious birth defect of the brain and spinal cord, researchers said.
“Vitamin B12 is essential for the functioning of the nervous system and for the production of red blood cells,” says Duane Alexander, MD, director of the National Institute of Child Health and Human Development, which funded the study. “The results of this study suggest that women with low levels of B12 not only may risk health problems of their own, but also may increase the chance that their children may be born with a serious birth defect.”
Irish women with the lowest vitamin B12 levels were five times more likely to have a baby with a neural tube defect than those with the highest levels, the researchers wrote in the journal Pediatrics.
As an aside, I used to tell people about B12 on any forum I could find. On an Irish forum I received many responses, but then my posts were deleted and I saw that the forum displayed advertising from drug companies. Karen 3/2/09
Night Shift work ~ Cancer link ~
Scientists at the International Agency for Research on Cancer (IARC) have found a possible link between night work and tumor formation. Although numerous studies suggested a link between night shift work and cancer, this is the first time it has been evaluated by the IARC, said Aaron Blair, scientist emeritus at the U.S. National Cancer Institute and chairman of the IARC Working Group that evaluated the shift work-cancer link.
On the epidemiological side, “there’s human data — nurses, airplane flight attendants, different groups that engage in shift work — that have an elevated risk of breast cancer, and that’s the strongest finding,” Blair said. ”There’s lesser evidence, but some positive evidence, for [increased risk of] prostate cancer, and a little less, but still positive, evidence, for colon cancer.” In animal studies, rats exposed to light during their nocturnal, active phase, also displayed spikes in cancer incidence, Blair said.
In investigations into possible biological mechanisms linking working through the wee hours to heightened odds for malignancy, the strongest theory involves melatonin, a hormone produced by the brain’s pineal gland. Shift workers interrupt their natural melatonin formation. 2007
Researchers in Hong Kong report that the hormone melatonin, more commonly used to reduce the effects of jetlag, could protect the brain from the effects of stroke. March, 2003
Gray’s Attorney Textbook of Medicine, says, “On physical examination… those with B12 deficiency frequently look flabby.” I believe the textbook says that to alert lawyers to the fact that a person does not have to be skinny, to be B12 anemic.
I know I looked flabby. (When I began eating for my blood type, as per D’Adamo, I lost 5 lb. a month by eating brown rice instead of pasta and bread, even though I ate more. I tried it because D’Adamo talks about how research showed that his diet guidelines reduce the symptoms of pernicious anemia. The diet reduces swelling at cell level. Also, the diet ended my diarrhea.) You can check it out at www.dadamo.com. There is a food database.